trifluoromethylphenylpiperazine

Trifluoromethylphenylpiperazine (TFMPP) is a synthetic small-molecule phenylpiperazine derivative that acts as a non-selective serotonin (5-HT) receptor agonist and serotonin releasing agent. It exhibits affinity for several serotonin receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT2. TFMPP is primarily known as a recreational designer drug, often sold under the street name Legal X, and is frequently co-administered with benzylpiperazine (BZP) to mimic the entactogenic and stimulant effects of MDMA (Ecstasy). While it has no approved therapeutic indications, it has been the subject of clinical research, including a randomized placebo-controlled trial sponsored by the New Zealand Ministry of Health to evaluate its effects on driving performance. Adverse effects associated with its use include anxiety, insomnia, nausea, vomiting, and seizures.

Other names

1-(3-trifluoromethylphenyl)piperazineLegal X