TriFol

TriFol is a branded nutraceutical combination product marketed by Sugen Pharma, primarily indicated for pregnancy support and the prevention of fetal deformities such as neural tube defects (NTDs). The formulation typically contains the biologically active forms of three essential B-vitamins: L-methylfolate (Vitamin B9), methylcobalamin (Vitamin B12), and pyridoxal 5-phosphate (Vitamin B6). Unlike synthetic folic acid, L-methylfolate does not require conversion by the enzyme methylenetetrahydrofolate reductase (MTHFR), making it particularly effective for individuals with MTHFR genetic polymorphisms. These components work synergistically to regulate homocysteine levels and support DNA synthesis and methylation, which are critical processes during preconception and pregnancy.

Brand names

TriFolTriFol-BTriFol-BD

Other names

L-methylfolate + methylcobalamin + pyridoxal 5-phosphate