TriFol-B

TriFol-B is a branded nutraceutical combination product marketed by Sugen Pharma, an Ahmedabad-based pharmaceutical company. It is primarily formulated for use in obstetrics and gynecology to support healthy pregnancy, prevent fetal deformities (such as neural tube defects), and manage hyperhomocysteinemia. The product typically contains the bioactive forms of essential B-vitamins: **L-methylfolate** (the active form of Vitamin B9), **methylcobalamin** (the active form of Vitamin B12), **pyridoxal-5-phosphate** (the active form of Vitamin B6), and **biotin** (Vitamin B7). By providing these vitamins in their metabolically active states, TriFol-B bypasses the enzymatic conversion steps required by synthetic folic acid and cyanocobalamin, ensuring optimal bioavailability even in individuals with genetic polymorphisms like MTHFR mutations. It plays a critical role in the one-carbon metabolism cycle, facilitating DNA synthesis and the conversion of homocysteine to methionine.

Brand names

TriFol-B

Other names

L-methylfolate + methylcobalamin + pyridoxal 5-phosphate + biotin