trilostane

Trilostane is a synthetic steroidogenesis inhibitor primarily used in veterinary medicine for the treatment of hyperadrenocorticism (Cushing’s disease) in dogs and cats, as well as alopecia X in dogs. It acts by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, thereby blocking the synthesis of adrenal steroids such as cortisol and aldosterone. This results in decreased production of glucocorticoids, mineralocorticoids, and sex hormones. Trilostane does not cure Cushing’s disease but helps manage its symptoms by reducing excessive hormone levels. In humans, it was previously used to treat Cushing's syndrome and Conn's syndrome but has been withdrawn from the U.S. market since 1994[3][4][1]. Trilostane is administered orally as a capsule with food.

Brand names

VetorylDesopanModrastaneModrenal

Other names

trilostanotrilostanum