TRIM72-containing exosome

TRIM72-containing exosome (also referred to as MG53-containing exosome or extracellular vesicle) is an investigational exosome-based therapeutic candidate designed to deliver tripartite motif-containing protein 72 (TRIM72, also known as mitsugumin 53 or MG53) to target tissues. TRIM72 is a muscle-enriched myokine that plays a critical role in cell membrane repair, mitochondrial preservation, and anti-inflammatory modulation. In preclinical models of acute kidney injury (such as ischemia-reperfusion injury) and chronic kidney disease, administration of TRIM72-containing exosomes successfully reconstituted TRIM72 expression in the kidney, suppressed NF-κB signaling, reduced pro-inflammatory cytokine levels, and mitigated elevated serum creatinine, demonstrating a protective effect against renal damage and subsequent fibrosis.

Other names

MG53-containing EVMG-53-containing EVMG 53-containing EVMG53-containing EVsMG-53-containing EVsMG 53-containing EVsMG53-containing exosomeMG-53-containing exosomeMG 53-containing exosomeMG53-containing exosomesMG-53-containing exosomesMG 53-containing exosomesMG53-containing extracellular vesicleMG-53-containing extracellular vesicleMG 53-containing extracellular vesicleMG53-containing extracellular vesiclesMG-53-containing extracellular vesiclesMG 53-containing extracellular vesiclesMG53-loaded EVMG-53-loaded EVMG 53-loaded EVMG53-loaded exosomeMG-53-loaded exosomeMG 53-loaded exosomeTRIM72-containing extracellular vesicleTRIM-72-containing extracellular vesicleTRIM 72-containing extracellular vesicleTRIM72-containing extracellular vesiclesTRIM-72-containing extracellular vesiclesTRIM 72-containing extracellular vesiclesTRIM72-loaded EVTRIM-72-loaded EVTRIM 72-loaded EVTRIM72-loaded exosomeTRIM-72-loaded exosomeTRIM 72-loaded exosome