trimegestone

Trimegestone is a synthetic progestin of the 19-norpregnane class, developed primarily for use in menopausal hormone therapy. It acts as a highly potent and selective agonist of the progesterone receptor, with an affinity significantly greater than that of natural progesterone. Trimegestone exhibits minimal activity at androgen, glucocorticoid, and mineralocorticoid receptors and has no estrogenic activity. Its primary clinical use is in combination with estrogens (such as estradiol) for postmenopausal hormone replacement therapy to provide endometrial protection and manage climacteric symptoms. The drug does not negate the beneficial effects of estrogen on lipid profiles and demonstrates favorable bleeding patterns compared to other progestins[2][3][5][6].

Brand names

OndevaTotelle

Other names

trimegestone74513-62-5Trimegestone [INN]Ru-27987Ru27987Ru 27987