Trimelin

Trimelio is an apparent spelling variant of **Trimelin**, a Hellix Healthcare-marketed oral fixed-dose antidiabetic combination containing glimepiride, metformin, and pioglitazone. Available Trimelin product records identify 2 mg/500 mg/15 mg tablets and 1 mg/500 mg/15 mg extended-release tablets for improving glycemic control in adults with type 2 diabetes mellitus alongside diet and exercise. Glimepiride stimulates pancreatic insulin release through sulfonylurea receptor-mediated closure of beta-cell ATP-sensitive potassium channels; metformin reduces hepatic glucose production and improves insulin sensitivity; and pioglitazone activates PPAR-gamma to improve insulin sensitivity. ([1mg.com](https://www.1mg.com/drugs/trimelin-2mg-500mg-15mg-tablet-521260))

Brand names

Trimelin

Other names

glimepiride + metformin + pioglitazoneTrimelio