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trimeric gp140 protein
- Development stage
- Phase 1
- Lead developer
- Janssen Pharmaceutical
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Trimeric gp140 protein is a recombinant, purified protein derived from the human immunodeficiency virus (HIV) envelope glycoprotein (Env). It is being developed as a vaccine to assess its safety, tolerability, and immunogenicity in healthy, HIV-uninfected adult volunteers. The vaccine aims to elicit an immune response, specifically neutralizing antibodies, against HIV-1 infection to prevent the virus from entering host cells. It can be administered intramuscularly, with or without an adjuvant such as aluminum phosphate. The development of this vaccine is led by Crucell Holland BV.
- Other names
- glycoprotein140glycoprotein-140glycoprotein 140
02
Targets
CD4 (T lymphocyte surface antigen)CXCR4 (C-X-C motif chemokine receptor 4)
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