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trimethoprim + sulfamethoxazole + edetate calcium disodium + ethanol

Development stage: Unknown
Lead developer: University of Texas MD Anderson Cancer Center
Modality: Small Molecules
Administration: Intracatheter

Overview

This investigational antimicrobial catheter lock solution (CLS) is a triple-combination formulation developed by the M.D. Anderson Cancer Center. It consists of trimethoprim-sulfamethoxazole (TMP-SMX), edetate calcium disodium (EDTA), and ethanol. The solution is specifically designed to prevent catheter-related bloodstream infections (CRBSI) and maintain catheter patency by preventing catheter occlusion in patients with malignancies who require central or peripheral venous catheters. Its multi-mechanistic approach includes the inhibition of bacterial dihydrofolate reductase and dihydropteroate synthase by TMP-SMX to block nucleic acid synthesis, the chelation of divalent cations by EDTA to disrupt microbial biofilms and provide anticoagulant properties, and the disruption of microbial cell membranes by ethanol.

Brand names: B-Lock
Other names: TMP-SMX-EDTA-ethanol catheter lock solutionAntimicrobial catheter lock solution

Targets

DHFR (Dihydrofolate reductase)DHPS (Dihydropteroate synthase)

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