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TRIO-TRAILBody
- Development stage
- Preclinical
- Lead developer
- TRIO Pharmaceuticals
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
TRIO-TRAILBody is a bispecific antibody immunotherapy developed by TRIO Pharmaceuticals using the proprietary TRAILBody™ platform. It utilizes a "naked antibody" approach to selectively induce apoptosis in both tumor cells and immunosuppressor cells by engaging the TRAIL (TNF-related apoptosis-inducing ligand) pathway. This mechanism aims to provide the potency of antibody-drug conjugates (ADCs) and CAR-T therapies with reduced toxicity to normal cells. The program is currently in preclinical development for the treatment of Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Ovarian Cancer, and Endometrial Cancer.
- Brand names
- TRAILBody
- Other names
- TRAILBody
02
Targets
TNFRSF10B (DR5)CD22 (Cluster of Differentiation 22)CD33 (Myeloid cell surface antigen CD33)
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