Drug intelligence / Profile preview

Triomar

Development stage
Phase 3
Lead developer
Orkla Health
Modality
Small Molecules
Administration
Oral
01

Overview

Triomar is a concentrated marine omega-3 fatty acid supplement consisting of fish oil triglycerides enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It typically contains a 60% concentration of omega-3 fatty acids, often standardized to a specific EPA to DHA ratio of approximately 3:2. Triomar is utilized for its anti-inflammatory and lipid-lowering properties and has been evaluated in various clinical settings, including as a potential immunomodulatory therapy for relapsing-remitting multiple sclerosis (RRMS) and for the management of cardiovascular health and hypertriglyceridemia. Its mechanism involves the modulation of lipid mediators, activation of nuclear receptors such as PPAR-alpha, and competitive inhibition of arachidonic acid metabolism to reduce the production of pro-inflammatory eicosanoids and cytokines.

Brand names
Triomar
Other names
omega-3 fatty acid concentrateomega3 fatty acid concentrateomega 3 fatty acid concentratefish oil triglyceride concentrateconcentrated omega-3 fatty acids
02

Targets

FFAR4 (Free fatty acid receptor 4)PGHS-1 (Prostaglandin G/H Synthase 1)ALOX5 (Arachidonate 5-lipoxygenase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PPARA (Peroxisome proliferator-activated receptor alpha)

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