Drug intelligence / Profile preview

Triphala-based Herbal Mouth Rinse

Development stage
Unknown
Lead developer
Manav Rachna International Institute of Research and Studies
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Triphala-based Herbal Mouth Rinse is an Ayurvedic herbal formulation used as an oral rinse to control dental plaque and gingival inflammation. Triphala is a traditional Ayurvedic mixture of three fruits: *Terminalia chebula* (Haritaki), *Terminalia bellerica* (Bibhitaki), and *Emblica officinalis* (Amalaki). It possesses broad-spectrum antimicrobial, antioxidant, and anti-inflammatory properties. In clinical studies, including those associated with the Manav Rachna International Institute of Research and Studies, Triphala-based mouth rinses have been evaluated for their feasibility and clinical efficacy in reducing plaque accumulation, gingival inflammation, and salivary levels of *Streptococcus mutans* in patients undergoing orthodontic treatments, such as clear aligner therapy, showing comparable efficacy to chlorhexidine without the associated side effects like tooth staining.

Other names
TriphalaTriphala mouth rinseTriphala mouthwashTriphala oral rinse
02

Targets

ADH1B (Alcohol dehydrogenase beta-1 subunit)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR (Epidermal growth factor receptor)ESR1 (ERα)GRIN1 (NMDA receptor subunit 1)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)MYD88 (Myeloid differentiation primary response protein MyD88)GPBAR1

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