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Triple-Mix
- Development stage
- Preclinical
- Lead developer
- Bavarian Nordic
- Modality
- Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Injection
01
Overview
Triple-Mix is an investigational vaccine candidate developed by Bavarian Nordic in collaboration with the Battelle Memorial Institute, designed to provide protection against three major alphaviruses: Venezuelan equine encephalitis virus (VEEV), Western equine encephalitis virus (WEEV), and Eastern equine encephalitis virus (EEEV). The approach involves a mixture of three separate monovalent vaccines, each utilizing the non-replicating Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN) viral vector platform. Each vector is engineered to express the structural envelope polyprotein (E3-E2-6K-E1) of its respective target virus. Preclinical studies in mice demonstrated that this 'Triple-Mix' strategy provides complete protection against lethal aerosol challenges from all three viruses. This research served as the foundation for the development of MVA-WEV, a single trivalent vaccine vector that incorporates antigens from all three viruses into a single MVA-BN backbone.
- Other names
- MVA-BN VEEV/WEEV/EEEV mixtureMVA-BN-VEEV + MVA-BN-WEEV + MVA-BN-EEEV
02
Targets
EEEV envelope polyprotein (Eastern equine encephalitis virus envelope polyprotein)WEEV structural protein (Western equine encephalitis virus structural polyprotein)VEEV E polyprotein (Venezuelan equine encephalitis virus envelope polyprotein)
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