tripterygium wilfordii ethyl acetate extract

Tripterygium wilfordii ethyl acetate extract is a pharmaceutical-grade herbal extract derived from the roots of the Chinese medicinal plant *Tripterygium wilfordii* Hook F, commonly known as Thunder God Vine. The extract is produced through a standardized sequential extraction process using ethanol followed by ethyl acetate. Its therapeutic activity is primarily attributed to diterpenoid epoxides, most notably triptolide and tripdiolide, which possess potent anti-inflammatory and immunosuppressive properties. The extract has been clinically evaluated in the United States for the treatment of autoimmune and inflammatory diseases, particularly rheumatoid arthritis and systemic lupus erythematosus. Its biological mechanism involves the inhibition of pro-inflammatory cytokine production and the modulation of T-cell and B-cell responses, partly through the inhibition of the transcription factor NF-kappaB and the targeting of the XPB subunit of the TFIIH complex, which interferes with RNA polymerase II-mediated transcription.

Other names

TwHF ethyl acetate extractethyl acetate extract of Tripterygium wilfordii Hook F