triptorelin

Triptorelin is a synthetic decapeptide agonist analog of gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH). It acts by binding to GnRH receptors in the pituitary gland and initially stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a temporary surge in sex hormones. With continued administration, it downregulates GnRH receptors leading to decreased LH and FSH production and subsequent suppression of gonadal steroidogenesis. This results in reduced testosterone levels in men and estrogen levels in women. Triptorelin is primarily used for the palliative treatment of advanced prostate cancer and for central precocious puberty (CPP) in children. It is also used off-label for conditions requiring suppression of sex hormones such as endometriosis or as part of gender-affirming therapy[1][2][3][4][5][7].

Brand names

TrelstarTriptodurDecapeptylDécapeptylDecapeptyl CRDecapeptyl DepotDecapeptyl LPDecapeptyl RetardDipherelineGonapeptylArvekapSalvacylVariopeptyl

Other names

triptorelin pamoate