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TriSTAR0703
- Development stage
- Preclinical
- Lead developer
- Marengo Therapeutics
- Modality
- Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
TriSTAR0703 is a trispecific antibody being developed by Marengo Therapeutics for the treatment of various oncology indications. It is built upon the proprietary TriSTAR (Trispecific T Cell Engager) platform, which is designed to selectively activate and expand a specific pool of memory Vβ T cells. Unlike traditional T cell engagers that can lead to T cell exhaustion, the TriSTAR platform aims to redirect highly potent memory T cells to the tumor microenvironment, specifically targeting 'cold' tumors that are typically resistant to standard immunotherapies. TriSTAR0703 is currently a partnered program, although the specific molecular targets and the identity of the partner have not been publicly disclosed.
02
Targets
CD28 (Cluster of Differentiation 28)TRBV (T-cell receptor beta variable chain family)MAGEA8 (Melanoma-associated antigen 8)γδ TCR (T-cell receptor)
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