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This is a vaccination regimen studied for interchangeability, involving the sequential administration of two different pentavalent combination vaccines: Tritanrix HB+Hib (manufactured by GSK) and Quinvaxem (manufactured by Berna Biotech Korea/Crucell). Both vaccines are designed to protect against diphtheria, tetanus, pertussis (whooping cough), hepatitis B, and Haemophilus influenzae type b (Hib) infections. The regimen typically consists of a primary dose of Tritanrix HB+Hib followed by subsequent doses of Quinvaxem. Clinical trials have demonstrated that this mixed schedule is non-inferior to a single-vaccine schedule, supporting the flexibility of pentavalent vaccine use in childhood immunization programs.
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