Drug intelligence / Profile preview

triticum vulgare aqueous extract

Development stage
Phase 4
Lead developer
Arterra Bioscience
Administration
Topical
01

Overview

Triticum vulgare aqueous extract is a hydrosoluble complex derived from the common wheat plant, specifically obtained from germinated whole plants using standardized procedures[1][5]. The extract is rich in oligosaccharides and other bioactive compounds, and it is primarily used for its wound-healing and tissue-regenerative properties in dermatology and skin care[1][5]. The mechanism of action includes stimulating fibroblast proliferation, enhancing actin polymerization, increasing synthesis of extracellular matrix components like fibronectin and hyaluronan, promoting lipid synthesis in keratinocytes, and reducing the expression of inflammatory mediators such as IL-6, TNFα, prostaglandin E2, and nitric oxide[1][5]. The extract modulates multiple phases of the wound healing process, including inflammation, cell proliferation, and tissue remodeling. It is marketed for topical use in management of skin ulcers, burns, superficial wounds, and minor skin irritations[2][3][4][5]. Clinical studies support its anti-inflammatory effects, capacity to accelerate wound closure, and role in improving skin barrier function[1][5].

Brand names
Fitostimoline
Other names
triticum vulgare extractTVERigenasewheat germ aqueous extract
02

Targets

HAS1 (Hyaluronan synthase 2)PGE2 (Prostaglandin E2)IL-6 (Interleukin 6)NO2- (Nitrite)TNFA (Tumor necrosis factor alpha (soluble))

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