trivalent inactivated influenza split vaccine

Trivalent inactivated influenza split vaccine (IIV3) is a seasonal vaccine formulation designed to protect against three strains of the influenza virus, typically including two influenza A subtypes (H1N1 and H3N2) and one influenza B lineage. The "split-virion" process involves using detergents to disrupt the inactivated virus, which helps maintain immunogenicity while reducing the risk of adverse reactions compared to whole-virus vaccines. The vaccine functions by stimulating the production of neutralizing antibodies against the viral hemagglutinin (HA) protein, thereby preventing viral attachment and entry into host cells. This specific study by the Zhejiang Provincial Center for Disease Control and Prevention evaluates the vaccine's safety and immunogenicity in immunocompromised populations, such as adults living with HIV.

Other names

IIV3IIV-3IIV 3trivalent influenza split vaccinetrivalent inactivated influenza vaccineinfluenza split vaccine (trivalent)