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The trivalent purified inactivated influenza vaccine is a biological vaccine developed by the Cantacuzino National Institute of Research and Development for Microbiology and Immunology (INCDMI Cantacuzino) in Romania. It is an inactivated (killed-virus) vaccine administered parenterally to prevent seasonal influenza. The vaccine contains purified hemagglutinin (HA) surface antigens from three influenza virus strains: two influenza A subtypes (typically H1N1 and H3N2) and one influenza B strain, updated annually based on World Health Organization (WHO) recommendations. It has been evaluated in Phase 3 clinical trials in Romania to assess safety, reactogenicity, and immunogenicity in both healthy adults and elderly populations.
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