trofosfamide

Trofosfamide is an orally bioavailable oxazaphosphorine prodrug and a derivative of cyclophosphamide. It acts as an alkylating agent, inhibiting cell division by cross-linking DNA strands and decreasing DNA synthesis. After oral administration, trofosfamide is metabolized predominantly to the cyclophosphamide analog ifosfamide and other active metabolites. It has antineoplastic activity and has been used in the treatment of various cancers, including soft tissue sarcomas, central nervous system tumors (such as ependymomas and medulloblastomas), carcinomas, lymphomas (notably non-Hodgkin's lymphoma), and recurrent brain tumors. Trofosfamide is often considered for maintenance or metronomic therapy due to its oral availability and relatively favorable safety profile[1][2][3][4][5][6][7][9].

Brand names

Ixoten

Other names

trophosphamidetrilophosphamideGenoxal TrofosfamidaN,N,N'-tris(2-chloroethyl)-N'-O-propylene phosphoric acid ester diamide