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Trolamine is a topical oil-in-water emulsion used for the management of radiation-induced dermatitis, superficial burns, and skin wounds. It acts by creating a moist healing environment and recruiting macrophages to the site of injury, which modulates the inflammatory response by altering the concentrations of immunomodulators such as IL-1 and IL-6. While it has been considered a reference topical agent in many institutions for patients undergoing radiotherapy, particularly for breast cancer, its prophylactic efficacy has been debated in comparative trials against other agents like calendula. It is also investigated for the treatment of radiation-induced vaginitis.
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