troleandomycin

Troleandomycin is a semi-synthetic macrolide antibiotic derived by acetylation of oleandomycin. It acts by binding to the 50S subunit of bacterial ribosomes, inhibiting translocation of tRNA and thereby blocking protein synthesis, which prevents bacterial growth. Troleandomycin is used for the treatment of various bacterial infections, particularly those affecting the upper and lower respiratory tract such as tonsillitis, bronchitis, sinusitis, and pneumonia. It also functions as a CYP3A4 inhibitor in humans and can interact with other drugs metabolized by this enzyme[1][2][4][5]. The drug was marketed under several brand names including Tao (now discontinued), Triocetin (Italy), and Tekmisin (Turkey)[2][4]. Troleandomycin has also been studied as an adjunct therapy in corticosteroid-dependent asthma due to its ability to inhibit steroid metabolism[6].

Brand names

TaoTriocetinTekmisin

Other names

triacetyl-oleandomycin