trovafloxacin

Trovafloxacin is a broad-spectrum antibiotic of the fluoroquinolone class, developed and marketed under the brand name Trovan. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and partitioning during cell division. This mechanism disrupts bacterial DNA processes leading to cell death. Trovafloxacin was primarily indicated for the treatment of infections such as gonorrhea (*Neisseria gonorrhoeae*), chlamydia (*Chlamydia trachomatis*), complicated intra-abdominal infections, nosocomial pneumonia, pelvic infections, skin and structure infections. The drug demonstrated greater efficacy against Gram-positive bacteria compared to earlier fluoroquinolones but was associated with severe hepatotoxicity (liver injury), including cases of acute liver failure and death. Due to these safety concerns, its use has been severely restricted or withdrawn in many countries[1][2][3][4][5].

Brand names

Trovan

Other names

trovafloxacin mesylate