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TRX-214

Development stage: Preclinical
Lead developer: Therapex
Modality: Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Intravenous

Overview

TRX-214 is a preclinical-stage degrader-antibody conjugate (DAC) being developed by Therapex for the treatment of solid tumors. As a DAC, the molecule combines the targeting specificity of a monoclonal antibody with the potent protein-clearing capability of a targeted protein degrader (TPD) payload. This modality is designed to overcome limitations of traditional antibody-drug conjugates (ADCs) by utilizing catalytic degradation of intracellular targets rather than stoichiometric killing. The specific antigen target and degrader mechanism for TRX-214 remain undisclosed by the developer.

Targets

GSPT1 (G1 to S phase transition 1)CD33 (Myeloid cell surface antigen CD33)

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