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TSG6dHep-Fc
- Development stage
- Preclinical
- Lead developer
- Halozyme
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
TSG6dHep-Fc is a recombinant fusion protein developed by Halozyme Therapeutics as a diagnostic imaging agent to detect hyaluronan (HA) accumulation in solid tumors. It consists of a fragment of the tumor necrosis factor-stimulated gene-6 (TSG6) protein, which has been mutated at its heparin-binding site (dHep) to reduce non-specific binding, fused to a human IgG1 Fc domain. TSG6dHep-Fc acts as a soluble HA-binding protein that can be labeled with imaging agents, such as the near-infrared fluorophore DyLight755, to non-invasively identify HA-rich malignancies. This tool was designed to facilitate patient selection for HA-targeting therapies, such as pegylated recombinant human hyaluronidase (PEGPH20), by confirming the presence of high HA levels in the tumor extracellular matrix and monitoring enzymatic activity.
- Other names
- TSG6dHep-FcDL755TSG-6dHep-FcDL755TSG 6dHep-FcDL755recombinant HA binding protein
02
Targets
C1Q (Complement C1q)ITIH (Inter-alpha-trypsin inhibitor heavy chain)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)FCGRT (Neonatal crystallizable fragment receptor)HS/HSPG (Heparin and heparan sulfate)
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