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TSY-120
- Development stage
- Preclinical
- Lead developer
- Formosa Pharmaceuticals
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
TSY-120 is a preclinical-stage antibody-drug conjugate (ADC) biosimilar developed by Formosa Pharmaceuticals. It is designed as a biosimilar to Enhertu (trastuzumab deruxtecan), targeting the human epidermal growth factor receptor 2 (HER2). The drug is intended for the treatment of HER2-positive and HER2-low breast cancers. TSY-120 consists of a humanized anti-HER2 monoclonal antibody covalently linked to a cytotoxic topoisomerase I inhibitor payload via a cleavable linker. By binding to HER2 on the surface of tumor cells, the ADC is internalized, and the payload is released to induce DNA damage and cell death, including a bystander effect on neighboring tumor cells.
- Other names
- TSY120TSY-120TSY 120
02
Targets
TOP1 (DNA Topoisomerase I)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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