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TT12
- Development stage
- Preclinical
- Lead developer
- Tessa Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**TT12** is a human papillomavirus specific T cell therapy (HPVST) developed for the treatment of HPV-associated cancers. It leverages engineered T cells targeting HPV antigens to elicit antitumor immune responses, primarily evaluated in oropharyngeal cancer and cervical cancer. This cell-based immunotherapy aims to provide durable responses in HPV-driven malignancies by harnessing T cell-mediated cytotoxicity against infected or transformed cells expressing HPV oncoproteins.
02
Targets
Human papillomavirus type 18 E6/E7 peptide-MHC class I complexHPV16 E6/HLA-A*02:01 (HPV16 E6 peptide-HLA-A*02:01 complex)
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