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TTI-621 + talimogene laherparepvec
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Oncolytic Viruses → Oncolytic Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intratumoral, Intravenous
01
Overview
The drug is a **combination therapy of TTI-621 and talimogene laherparepvec**. - **TTI-621 (SIRPα-IgG1 Fc)** is a recombinant fusion protein that acts as a decoy receptor for CD47, blocking the "don't eat me" signal and activating tumor cell phagocytosis by macrophages via its IgG1 Fc region. - **Talimogene laherparepvec (T-Vec, Imlygic)** is an oncolytic immunotherapy derived from a genetically modified herpes simplex virus type-1 (HSV-1) that replicates within tumors and produces the immune stimulatory protein granulocyte-macrophage colony stimulating factor (GM-CSF), inducing direct tumor lysis and promoting local and systemic antitumor immune responses. - The combination seeks to enhance antitumor immunity through both the innate (macrophage activation via CD47 blockade) and adaptive immune responses (T-cell mediated, promoted by oncolysis and GM-CSF expression). This combination has been assessed in patients with unresectable melanoma[3][5].
- Brand names
- Imlygic
- Other names
- ImlygicT-VecSIRPα-IgG1 Fc
02
Targets
CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)CD47 (Cluster of Differentiation 47)
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