TU-514

TU-514 is a small molecule experimental compound classified as a fatty acid ester. It has the chemical formula C22H41NO7 and an average molecular weight of 431.56. TU-514 functions as a substrate analog inhibitor of LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase), an essential zinc-dependent enzyme involved in the first committed step of lipid A biosynthesis in Gram-negative bacteria. By binding to LpxC, TU-514 inhibits this critical pathway for lipopolysaccharide (LPS) production, making it a potential antibiotic lead targeting Gram-negative bacterial infections[1][9]. Structural studies have shown that TU-514 interacts with the unique zinc-binding motif and hydrophobic passage within LpxC, providing insights into its mechanism and supporting its use as a tool compound for antibiotic development[9]. The drug is under investigation primarily in oncology research but has not advanced beyond preclinical or early experimental stages[2][4].

Other names

1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-