tubacin

**Tubacin** is a highly potent, selective, reversible, and cell-permeable small molecule inhibitor of **histone deacetylase 6 (HDAC6)**. Tubacin increases acetylation of α-tubulin without significantly affecting histone acetylation, thereby influencing processes such as microtubule dynamics, intracellular transport, and protein degradation. It has a strong antiproliferative and pro-apoptotic effect in various cancer cell lines, and enhances the effects of other anticancer drugs. Tubacin is primarily used as a research chemical probe for HDAC6 due to its poor drug-like properties, including high molecular weight and lipophilicity, which limit in vivo utility[2][3][4][6][7].

Other names

Octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-N-[4-[(2R,4R,6S)-4-[[4,5-di(phenyl)-1,3-oxazol-2-yl]sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide