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tuberculin purified protein derivative
- Development stage
- Approved
- Lead developer
- Sanofi
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intradermal, Intralesional
01
Overview
Tuberculin purified protein derivative (PPD) is a diagnostic biologic used to identify individuals infected with *Mycobacterium tuberculosis*. It consists of a sterile, purified fraction of the soluble growth products of the tubercle bacillus. When administered intradermally (the Mantoux test), it serves as a recall antigen that triggers a Type IV delayed-type hypersensitivity (DTH) reaction in persons with prior exposure to TB. This reaction, characterized by localized induration and erythema, is mediated by sensitized T-lymphocytes that migrate to the injection site and release pro-inflammatory cytokines. Beyond its primary diagnostic role, PPD is being investigated as an intralesional immunotherapeutic agent for conditions like anogenital warts and certain cancers, leveraging its ability to stimulate a potent Th1-biased immune response.
- Brand names
- AplisolTubersolJiemin
- Other names
- Tuberculin PPDMantoux test reagentTuberculin Purified Protein Derivative (Mantoux)
02
Targets
MHC II (Major histocompatibility complex class II receptor)
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