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tucidinostat + apatinib
- Development stage
- Unknown
- Lead developer
- Akeso
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of tucidinostat (formerly known as chidamide), an orally available selective histone deacetylase (HDAC) inhibitor that targets HDAC1, 2, 3, and 10, and apatinib, a tyrosine kinase inhibitor primarily targeting vascular endothelial growth factor receptor-2 (VEGFR-2). This combination is being investigated for its potential synergistic effects in treating various cancers, particularly relapsed or refractory osteosarcoma and advanced esophageal cancer.
- Brand names
- EpidazaAiTan
- Other names
- ChidamideRivoceranibTucidinostat and Apatinib
02
Targets
HDAC11 (Histone Deacetylase 11)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR2 (Vascular endothelial growth factor receptor 2)HDAC10 (Histone Deacetylase 10)HDAC1 (Histone Deacetylase 1)HDAC8 (Histone Deacetylase 8)VEGFR-1 (Vascular endothelial growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)
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