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tumor-infiltrating lymphocytes (Sun Yat-sen University)
- Development stage
- Unknown
- Lead developer
- Sun Yat-sen University Cancer Center
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
This autologous tumor-infiltrating lymphocyte (TIL) therapy is an adoptive cell therapy being developed by Sun Yat-sen University for the treatment of locally advanced cervical carcinoma (FIGO stages IIIA-IVA). The therapeutic process involves surgically removing a portion of the patient's tumor to isolate naturally occurring TILs, which are then expanded to large populations ex vivo. Following a regimen of cisplatin-based concurrent chemoradiotherapy (CCRT), the expanded TILs are reinfused into the patient to provide a robust, personalized immune response against tumor-associated antigens. This approach aims to enhance the curative potential of standard-of-care chemoradiotherapy by leveraging the specific anti-tumor activity of the patient's own immune cells.
- Other names
- autologous tumor-infiltrating lymphocytesTIL therapy
02
Targets
MHC I (MHC class I})
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