tumor necrosis factor-α

Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced primarily by activated macrophages and other immune cells. It plays a central role in inflammation and immune regulation. In the context of disease treatment, most clinical applications target inhibition of TNF-α rather than administration of the cytokine itself. However, in experimental settings such as cancer therapy (e.g., intratumoral injection for pancreatic cancer), recombinant or adenovector-delivered TNF-α has been investigated for its ability to induce tumor cell death and enhance immune responses[6][8]. The mechanism involves binding to specific receptors on target cells, leading to activation of signaling pathways that can result in apoptosis or necroptosis.

Brand names

AurasolMesoGold

Other names

Tumor Necrosis Factor-alphaCachectinTNFalpha