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Tumor-shrinking Decoction (TSD) is a traditional Chinese medicine formula composed of 15 individual Chinese medicines. It is developed for the treatment of symptomatic uterine fibroids (UFs). The formula is designed to address the deficiency of vital energy and blood stasis, which are considered causes of UFs in Traditional Chinese Medicine (TCM). Its components are categorized by TCM actions: tonifying qi and resolving phlegm (Astragalus Membranaceus, Semen Coicis, Poria, Curcuma longa L, Fritillaria Thunbergii Miq), resolving stasis, stopping bleeding, and relieving pain (Cassia twig, Pollen typhae, Resina draconis, Lithospermum erythrorhizon, Halloysitum Rubrum, Rhizoma Corydalis processed with vinegar), and softening hardness and dissipating binds (Hirudo, Calcined corrugated sub, Oyster Shell, Laminaria Japonica Aresch). Preclinical studies have indicated that TSD robustly inhibits fibroid cell growth and proliferation.
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