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Tumor-Suppressing Multi-Enterobacteria

Development stage: Preclinical
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Tumor-Suppressing Multi-Enterobacteria (TSME) is a microbial therapy being investigated for its potential to improve the efficacy of immunotherapy in patients with hepatocellular carcinoma (HCC). It is designed to influence the gut microbiota, which in turn can significantly impact immune responses and the effectiveness of immune checkpoint inhibitors (ICIs). Studies are exploring its combination with PD-L1 inhibitors, such as atezolizumab, particularly in cases of immunotherapy-resistant HCC.

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