Drug intelligence / Profile preview

tunodafil hydrochloride

Development stage
Phase 3
Lead developer
Yangtze River Pharmaceutical Group
Modality
Small Molecules
Administration
Oral
01

Overview

**Tunodafil hydrochloride** is an oral **small-molecule phosphodiesterase type 5 inhibitor** being developed by **Yangtze River Pharmaceutical Group** for **erectile dysfunction**. Public clinical-trial records describe **tunodafil hydrochloride tablets** in randomized, double-blind, placebo-controlled studies in men with erectile dysfunction, including a Phase 3 program, and published clinical pharmacology work has evaluated its interaction with alcohol as well as drug-drug interactions with ritonavir and omeprazole. The pharmacology is consistent with other PDE5 inhibitors: inhibition of PDE5 increases cyclic guanosine monophosphate signaling in corpus cavernosum smooth muscle, promoting vasodilation and facilitating penile erection in response to sexual stimulation.

Other names
tunodafilyonkenafil hydrochlorideyonkenafilyoukenafil
02

Targets

PDE5 (Phosphodiesterase 5A)CYP2C19 (Cytochrome P450 2C19)

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