Drug intelligence / Profile preview

turmeric + curcumin complex

Development stage
Unknown
Lead developer
Sabinsa
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Turmeric + curcumin complex is a **dietary supplement** composed of an extract from the root of Curcuma longa (turmeric) and its primary bioactive component, curcumin. These formulations often contain a high percentage of standardized curcuminoids (such as 95% curcumin extract) and may include absorption enhancers like piperine (BioPerine) from black pepper. Turmeric has been used for centuries in traditional medicine for its **anti-inflammatory, antioxidant, antimicrobial, immunoregulatory, chemopreventive, and analgesic effects**. Curcumin's mechanism of action includes modulating several molecular targets involved in inflammation, oxidative stress, and cellular signaling, such as **inhibition of cyclooxygenase (COX), inducible nitric oxide synthase (iNOS), lipoxygenase, xanthine oxidase, protein kinase C (PKC), tyrosine kinase, NF-κB**, and many others. These supplements are primarily used for joint support, wellness, and as adjuncts for managing chronic inflammatory and metabolic conditions.

Brand names
Regenexx Turmeric Curcumin Complex
Other names
turmeric and curcumin complexturmeric with curcumin
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)XO (Xanthine Oxidoreductase)NOS2 (Nitric Oxide Synthase 2)mTOR (Mammalian target of rapamycin kinase)15-LOX (Lysyl Oxidase)

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