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tusamitamab ravtansine
- Development stage
- Discontinued
- Lead developer
- Sanofi
- Modality
- Recombinant Proteins and Enzymes, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Tusamitamab ravtansine is an antibody-drug conjugate (ADC) designed to target tumor cells expressing carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). It consists of a humanized monoclonal antibody selective for the extracellular domain of CEACAM5, linked via a cleavable disulfide linker to DM4, a potent cytotoxic maytansinoid payload. Upon intravenous administration, the antibody binds to CEACAM5 on tumor cells and is internalized; intracellular cleavage releases DM4, which inhibits microtubule assembly leading to cell-cycle arrest and apoptosis. The drug was primarily developed for advanced solid tumors with high CEACAM5 expression, especially non-squamous non-small cell lung cancer (NSCLC). Sanofi discontinued its global clinical development in December 2023 after failing to meet primary endpoints in Phase 3 trials for NSCLC[1][2][3][4][6].
- Other names
- maytansin-loaded anti-ceacam5 mab
02
Targets
CEACAM5 (Carcinoembryonic antigen related cell adhesion molecule 5)TUBB (Tubulin (alpha and beta subunits))
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