Drug intelligence / Profile preview

TV005

Development stage: Phase 1
Lead developer: Merck
Modality: Vaccines & Immunotherapeutics
Administration: Subcutaneous

Overview

TV005 is an investigational, single-dose **live-attenuated tetravalent dengue vaccine** developed by the National Institute of Allergy and Infectious Diseases. It is an admixture of attenuated recombinant dengue virus components representing dengue virus serotypes 1, 2, 3, and 4; compared with the related TV003 formulation, TV005 contains a ten-fold higher dose of its DENV-2 component to improve DENV-2 immunogenicity. The vaccine is intended to induce protective humoral and cellular immunity against all four dengue serotypes and has been evaluated in phase 1 and phase 2 studies, including controlled human infection studies showing protection against attenuated DENV-2 and DENV-3 challenge viruses. ([jci.org](https://www.jci.org/articles/view/173328))

Other names: TetraVax-DVTetraVax-DV TV005TetraVax-DV-TV005TetraVax-DV-TV-005TetraVax-DV-TV 005

Targets

CD209 (Dendritic cell-specific intercellular adhesion Molecule-3-Grabbing non-integrin)HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))PRR (Pattern recognition receptors)

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