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TVGV-HBV
- Development stage
- Unknown
- Lead developer
- TVAX Biomedical
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
TVGV-HBV (also known as TVG-HBV) is a therapeutic DNA vaccine candidate developed by T-Vax, Inc. for the treatment of chronic hepatitis B virus (HBV) infection. The vaccine is designed to break the immune tolerance observed in chronic HBV patients by stimulating a multi-specific T-cell response against several viral proteins. It consists of a DNA plasmid vector encoding the HBV core antigen (HBcAg), surface antigen (HBsAg), and the viral polymerase. By delivering these antigens directly to host cells, TVGV-HBV aims to induce both CD4+ helper and CD8+ cytotoxic T-cell activities, potentially leading to the clearance of HBV-infected hepatocytes and achieving a functional cure. The vaccine has been evaluated in early-stage clinical trials to assess its safety and immunogenicity.
- Other names
- TVG-HBVT-Vax HBV vaccine
02
Targets
HBc (Hepatitis B virus core protein)HBsAg (Hepatitis B surface antigen)HBV Pol (Hepatitis B virus polymerase)
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