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TVI-Brain 1
- Development stage
- Phase 3
- Lead developer
- TVAX Biomedical
- Modality
- Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
TVI-Brain 1 is an autologous cell-based immunotherapy developed by TVAX Biomedical for the treatment of recurrent glioblastoma multiforme (GBM) and other high-grade gliomas. The treatment utilizes the TVAX Immunotherapy platform, which involves a two-step process: first, the patient is vaccinated with irradiated, neutralized autologous tumor cells to prime the immune system against tumor-specific antigens. Following this priming, the patient's white blood cells are collected via leukapheresis, and the tumor-reactive T cells are stimulated and expanded ex vivo. These activated 'killer' T cells are then reinfused into the patient to target and eliminate cancer cells. The therapy has completed Phase 2 trials and has been granted U.S. FDA Orphan Drug Designation for the treatment of glioblastoma.
- Brand names
- TVAX Immunotherapy
- Other names
- TVAX Immunotherapy
02
Targets
pMHC (Peptide-MHC complex family)
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