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TVI-Lung-1
- Development stage
- Unknown
- Lead developer
- TVAX Biomedical
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
TVI-Lung-1 is an autologous adoptive T-cell therapy being developed by TVAX Biomedical for the treatment of lung cancer. The therapy is based on the TVAX Immunotherapy platform, which employs a unique two-step approach: first, the patient is vaccinated with their own irradiated tumor cells and an adjuvant (GM-CSF) to prime the immune system; second, the resulting tumor-specific T cells are harvested from the patient's blood, expanded and activated ex vivo, and then re-infused into the patient. These activated killer T cells are designed to recognize and eliminate cancer cells throughout the body, including those that may have metastasized. TVI-Lung-1 is currently in Phase 1 clinical trials.
02
Targets
pMHC-I (Peptide–MHC class I complex)
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