TW-37

TW-37 is an investigational drug identified as an inhibitor of KIM-1-mediated endocytosis. By inhibiting this process, TW-37 is thought to suppress the activation of the NLRP3 inflammasome, DNA damage response, cell cycle arrest, cellular senescence, and the production of inflammatory and fibrotic cytokines. It is also known as a senescent cell eliminator, inducing cell death in senescent cells. In preclinical studies using human renal proximal tubular epithelial cells, TW-37 treatment decreased the expression of KIM-1, NF-κB, IL-1β, and p16, and also reduced PD-L1 expression, suggesting anti-inflammatory, anti-aging, and renoprotective effects.