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Twinrix + Decavac

Development stage: Unknown
Lead developer: GSK
Modality: Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

Twinrix + Decavac refers to the co-administration of two distinct vaccine products in a clinical research context sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). Twinrix is a bivalent vaccine manufactured by GSK that provides active immunization against Hepatitis A (inactivated virus) and Hepatitis B (recombinant surface antigen). Decavac, manufactured by Sanofi Pasteur, is a divalent vaccine containing diphtheria and tetanus toxoids. This specific combination was utilized in a pilot study (NCT00096122) to investigate immune system responsiveness in patients with HIV-1, Hepatitis C (HCV), or HIV/HCV co-infection. The study aimed to identify biological determinants that predict how immunocompromised individuals respond to standard immunization protocols.

Brand names: TwinrixDecavac
Other names: Twinrix-National Institute of Allergy and Infectious Diseases (NIAID)-hepatitis A-hepatitis B-diphtheria

Targets

HBsAg (Hepatitis B surface antigen)TT (Tetanus toxoid)Hepatitis A virus capsid protein

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