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TXA15054

Development stage: Preclinical
Lead developer: TAXIS Pharmaceuticals
Modality: Small Molecules
Administration: Oral

Overview

TXA15054 is a small molecule dihydrofolate reductase (DHFR) inhibitor being developed by TAXIS Pharmaceuticals. It is currently in the lead optimization stage for the treatment of drug-resistant gonorrhea ('Super Gonorrhea') and Chlamydia. The drug works by disrupting bacterial folate metabolism, which is essential for DNA synthesis and bacterial growth. By targeting DHFR, TXA15054 aims to overcome resistance mechanisms prevalent in current antibiotic treatments for sexually transmitted infections.

Targets

DHFR (Dihydrofolate reductase (Neisseria gonorrhoeae))

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