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TXN10128 + paclitaxel
- Development stage
- Unknown
- Lead developer
- Txinno Bioscience
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
**TXN10128 + paclitaxel** is an investigational combination therapy being studied in adults with locally advanced or metastatic solid tumors that have relapsed or are refractory to standard treatment. TXN10128 is a small molecule inhibitor of ENPP1 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 1), designed to disrupt ENPP1-mediated pathways involved in tumor progression. Paclitaxel is a well-established microtubule-stabilizing chemotherapeutic agent that inhibits cell division, approved for multiple cancer indications. The combination is delivered as oral TXN10128 and intravenous paclitaxel, with a Phase 1 clinical trial currently recruiting to evaluate safety, pharmacokinetics, pharmacodynamics, and antitumor activity in solid tumors, including specific arms for breast cancer patients[1][2].
- Other names
- TXN10128 + paclitaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))ENPP1
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