Drug intelligence / Profile preview

TYP04A

Development stage
Unknown
Lead developer
Hangzhou Miracogen
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

**TYP04A** is a low-dose, alum-free formulation of an investigational bivalent conjugate vaccine designed to prevent enteric fever caused by *Salmonella enterica* serovar Typhi and serovar Paratyphi A. It was evaluated as a two-dose intramuscular priming and booster regimen in a randomized Phase 1 study in healthy adults. TYP04A is one formulation within GSK's typhoid-paratyphoid A conjugate vaccine program and is distinct from alum-containing and full-dose trial formulations. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05613205?tab=researcher))

Other names
Typhoid and Paratyphoid A conjugate low dose without adjuvant vaccine
02

Targets

TUBB (Tubulin (alpha and beta subunits))F3 (Tissue factor)

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