Type 2 collagen

Type 2 collagen is a major structural protein found in cartilage and is widely used as a dietary supplement and nutraceutical for joint health. In the context of osteoarthritis, it is believed to function through a mechanism known as oral tolerance. When ingested in small amounts, the protein interacts with gut-associated lymphoid tissue (GALT), which helps to desensitize the immune system and suppress the inflammatory T-cell response against endogenous type II collagen in the joints. This modulation helps to reduce joint pain, inflammation, and cartilage degradation. In clinical research sponsored by TCI Co., Ltd., Type 2 collagen has been utilized as a positive control in studies evaluating the efficacy of other interventions, such as the probiotic TCI633, for the treatment of knee osteoarthritis.

Other names

Collagen type IIType II collagenNative type II collagenUndenatured type II collagen